The Bauer Research Foundation (BRF) is committed to promoting human and animal health by educating the public as to the importance of one-carbon metabolism and its role in supporting normal cellular functioning, normal aging, as well as optimal neurologic and cardiovascular functioning.
Dr. Bauer, a biochemist with 26 years experience in health and science, has curated a list of supplements from Thorne based on evidence based science that help promote human and animal health.
One-carbon metabolism involves a series of interdependent biochemical cycles that are vital to normal nerve protection and function. Normal activity of these cycles is dependent upon several cofactors, including 5-methyltetrahydrofolate (5-MTHF; the biologically active form of folate), pyridoxal 5' phosphate (vitamin B6) and the biologically active methyl- and adenosyl- forms of cobalamin (Me-Cbl, Ado-Cbl; vitamin B12).
Studies have demonstrated deficiencies in physiologic levels of these cofactors in aging populations [1-3]. Cofactor deficiencies and the resultant disruptions in one-carbon metabolic cycles are associated with significant adverse neurologic consequences which have been linked to clinical development and progression of several neurodegenerative disorders [4-6]. Markers of one-carbon metabolism such as methylmalonic acid (MMA) and homocysteine (HCY), are often assessed in patients with neurological diseases, depression, and dementia [7-9]. Homocysteine is one of the most toxic molecules in the human body and has been implicated in unhealthy aging, macular degeneration, cardiovascular disease, Parkinson's disease, Alzheimer's disease, as well as cancer [10-16].
Supplementation with vitamin B12 and methylfolate have been shown to promote one carbon metabolism and lower HCY [17-18] which may be beneficial to those with a functional deficiency in vitamin B12 and/or MTHFR mutations. Check out the Methylation Bundle.
In addition, the BRF is committed to helping provide nutraceutical support for cancer patients. Several studies have demonstrated anti-cancer activity of these nutraceuticals in addition to helping lessen unwanted side-effects of chemotherapy: Vitamin D-5000, Omega 3 with CoQ10, R-lipoic acid, Carnityl® Acetyl-L-Carnitine, Phytoprofen (bromelain, ginger, Boswellia), curcumin phytosome: Meriva 500-SF (Certified for Sport), Boswellia Phytosome, melatonin, and Beta Alanine-SR.
Dr. Bauer also selected prenatal, youth, and healthy aging supplement bundles to promote health and well being for all ages. It's never too early nor too late to optimize one's health! Please visit our Thorne on-line Dispensary:
5. Blasko I, Hinterberger M, Kemmler G et al. Conversion from mild cognitive impairment to dementia: influence of folic acid and vitamin B12 use in the VITA cohort. J Nutr Health Aging 2012; 16(8):687-694. 6. Coppede F, Tannorella P, Pezzini I et al. Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls. Antioxid Redox Sign 2012; 17(2):195-204.
10. Tinelli C, Di Pino A, Ficulle E, Marcelli S, Feligioni M. Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies. Front Nutr. 2019;6:49. Published 2019 Apr 24.
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