The Bauer Research Foundation (BRF) is committed to promoting human and animal health by educating the public as to the importance of one-carbon metabolism and its role in supporting normal cellular functioning, normal aging, as well as optimal neurologic and cardiovascular functioning.


Dr. Bauer, a biochemist with 26 years experience in health and science, has curated a list of supplements from Thorne based on evidence based science that help promote human and animal health.


One-carbon metabolism involves a series of interdependent biochemical cycles that are vital to normal nerve protection and function. Normal activity of these cycles is dependent upon several cofactors, including 5-methyltetrahydrofolate (5-MTHF; the biologically active form of folate), pyridoxal 5' phosphate (vitamin B6) and the biologically active methyl- and adenosyl- forms of cobalamin (Me-Cbl, Ado-Cbl; vitamin B12).


Studies have demonstrated deficiencies in physiologic levels of these cofactors in aging populations [1-3]. Cofactor deficiencies and the resultant disruptions in one-carbon metabolic cycles are associated with significant adverse neurologic consequences which have been linked to clinical development and progression of several neurodegenerative disorders [4-6]. Markers of one-carbon metabolism such as methylmalonic acid (MMA) and homocysteine (HCY), are often assessed in patients with neurological diseases, depression, and dementia [7-9]. Homocysteine is one of the most toxic molecules in the human body and has been implicated in unhealthy aging, macular degeneration, cardiovascular disease, Parkinson's disease, Alzheimer's  disease, as well as cancer [10-16].


Supplementation with vitamin B12 and methylfolate have been shown to promote one carbon metabolism and lower HCY [17-18] which may be beneficial to those with a functional deficiency in vitamin B12 and/or MTHFR mutations. Check out the Methylation Bundle.




In addition, the BRF is committed to helping provide nutraceutical support for cancer patients. Several studies have demonstrated anti-cancer activity of these nutraceuticals in addition to helping lessen unwanted side-effects of chemotherapy: Vitamin D-5000, Omega 3 with CoQ10, R-lipoic acid, Carnityl® Acetyl-L-Carnitine, Phytoprofen (bromelain, ginger, Boswellia), curcumin phytosome: Meriva 500-SF (Certified for Sport), Boswellia Phytosome, melatonin, and Beta Alanine-SR.


Dr. Bauer also selected prenatal, youth, and healthy aging supplement bundles to promote health and well being for all ages. It's never too early nor too late to optimize one's health! Please visit our Thorne on-line Dispensary:






REFERENCES:

1. Selhub J, Jacques PF, Wilson PW et al. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J Am Med Assoc 1993; 270(22):2693-2698.

2. Wong CW. Vitamin B deficiency in the elderly: is it worth screening? Hong Kong Med J 2015; 21(2):155-164.

3. Kjeldby IK, Fosnes GS, Ligaarden SC and Farup PG. Vitamin B6 deficiency and diseases in elderly people--a study in nursing homes. BMC Geriatr 2013; 13:13.

4. Ansari R, Mahta A, Mallack E and Luo JJ. Hyperhomocysteinemia and neurologic disorders: a review. J Clin Neurol 2014; 10(4):281-288.

5. Blasko I, Hinterberger M, Kemmler G et al. Conversion from mild cognitive impairment to dementia: influence of folic acid and vitamin B12 use in the VITA cohort. J Nutr Health Aging 2012; 16(8):687-694. 6. Coppede F, Tannorella P, Pezzini I et al. Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls. Antioxid Redox Sign 2012; 17(2):195-204.

7. Seshadri S, Beiser A, Selhub J, Jacques PF et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. New Engl J Med 2002; 346(7):476-483.

8. Obeid R, McCaddon A and Herrmann W. The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases. Clin Chem Lab Med 2007; 45(12):1590-1 606.

9. Zylberstein DE, Lissner L, Bjorkelund C et al. Midlife homocysteine and late-life dementia in women. A prospective population study. Neurobiol Aging 2011; 32(3):380-386

​10. Tinelli C, Di Pino A, Ficulle E, Marcelli S, Feligioni M. Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies. Front Nutr. 2019;6:49. Published 2019 Apr 24.

11. Rochoy M, Rivas V, Chazard E, et al. Factors Associated with Alzheimer's Disease: An Overview of Reviews. J Prev Alzheimers Dis. 2019;6(2):121-134.

12. Zhou F, Chen S. Hyperhomocysteinemia and risk of incident cognitive outcomes: An updated dose-response meta-analysis of prospective cohort studies. Ageing Res Rev. 2019;51:55-66.

13. Paul R, Borah A. L-DOPA-induced hyperhomocysteinemia in Parkinson's disease: Elephant in the room. Biochim Biophys Acta. 2016;1860(9):1989-1997.

14. Pinna A, Zaccheddu F, Boscia F, Carru C, Solinas G. Homocysteine and risk of age-related macular degeneration: a systematic review and meta-analysis. Acta Ophthalmol. 2018;96(3):e269-e276.

15. Hasan T, Arora R, Bansal AK, Bhattacharya R, Sharma GS, Singh LR. Disturbed homocysteine metabolism is associated with cancer. Exp Mol Med. 2019;51(2):1-13. Published 2019 Feb 21.

​16. McCully KS. Review: Chemical Pathology of Homocysteine VI. Aging, Cellular Senescence, and Mitochondrial Dysfunction. Ann Clin Lab Sci. 2018;48(5):677-687.

​17. Kaye AD, Jeha GM, Pham AD, et al. Folic Acid Supplementation in Patients with Elevated Homocysteine Levels. Adv Ther. 2020;37(10):4149-4164.

18. Tanaka K, Ao M, Kuwabara A. Insufficiency of B vitamins with its possible clinical implications. J Clin Biochem Nutr. 2020;67(1):19-25.



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